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落花生主要アレルゲンタンパク質のマウスにおける抗原性
https://doi.org/10.24514/00000354
https://doi.org/10.24514/00000354f9436a8c-bfe8-43f5-bf91-ad6849e2a16e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
nfri_kenkyuhoukoku02_06.pdf (1.2 MB)
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| Item type | 紀要論文01 / Departmental Bulletin Original Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-16 | |||||
| タイトル | ||||||
| タイトル | 落花生主要アレルゲンタンパク質のマウスにおける抗原性 | |||||
| タイトル | ||||||
| タイトル | Allergenicity of major allergenic peanut proteins on Balb/c mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | peanut allergen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ara h1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ara h2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ara h3 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | antibody titer | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.24514/00000354 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
八巻, 幸二
× 八巻, 幸二× 高橋, 陽子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Using the simple purification method of the peanut antigenic proteins which we have developed before, we purified three kinds of allergenic protein from a peanut species and investigated the antigenicity against each protein and cross reactivity with the Balb/c mouse by alum immunization. Ara h1, Ara h2 and Ara h3, which was three kinds of major allergen, were injected in the abdominal cavity of the mouse with aluminum hydroxide gel for immunization. Two weeks later, blood was collected by cardiac puncture, the serum was measured antibody titer by enzyme linked immunosorbent assay. As a result, Ara h1 and h3 antibodies were increased more than Ara h2 antibody in IgG1 and IgG2a subclasses. It is reported that this Ara h2 shows a serious allergic symptom with the allergen of the peanut in human. However, there are increased antibody titer on h1 and h3 in this experiments with using the arum adjuvant. and it seems that it is important for the immunity model of the mouse to establish mouse allergic model of peanut allergens. In addition, it is suggested that the possibility of different antigenicity from human allergy disease to mouse allergic model. | |||||
| 書誌情報 |
農研機構研究報告 食品研究部門 en : Bulletin of the NARO,Food Research 号 2, p. 35-40, 発行日 2018-03 |
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| 出版者 | ||||||
| 出版者 | 国立研究開発法人 農業・食品産業技術総合研究機構 | |||||
| 出版者 | ||||||
| 出版者 | National Agriculture and Food Research Organization (NARO) | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2432-7891 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.24514/00000354 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
