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Interference of carbidopa and other catechols with reactions catalyzed by peroxidases
https://repository.naro.go.jp/records/2832
https://repository.naro.go.jp/records/2832f2a22a0f-d94f-42e6-8099-2d25ad2418b9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
SC30201810090008_postprintA (637.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-10-04 | |||||
| タイトル | ||||||
| タイトル | Interference of carbidopa and other catechols with reactions catalyzed by peroxidases | |||||
| タイトル | ||||||
| タイトル | Interference of carbidopa and other catechols with reactions catalyzed by peroxidases | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | carbidopa | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | catechol | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | hydrazine | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | peroxidase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | enzymatic assay interference | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Parkinson’s disease | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yuki, Nishigaya
× Yuki, Nishigaya× 山崎, 俊正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: A number of compounds, including ascorbic acid, catecholamines, flavonoids, p-diphenols and hydrazine derivatives have been reported to interfere with peroxidase-based medical diagnostic tests (Trinder reaction) but the mechanisms of these effects have not been fully elucidated. Methods: Reactions of bovine myeloperoxidase with o-dianisidine, bovine lactoperoxidase with ABTS and horse radish peroxidase with 4-aminoantipyrine/phenol in the presence of carbidopa, an anti-Parkinsonian drug, and other catechols, including L-dopa, were monitored spectrophotometrically and by measuring hydrogen peroxide consumption. Results: Chromophore formation in all three enzyme/substrate systems was blocked in the presence of carbidopa and other catechols. However, the rates of hydrogen peroxide consumption were not much affected. Irreversible enzyme inhibition was also insignificant. Conclusions: Tested compounds reduced the oxidation products or intermediates of model substrates thus preventing chromophore formation. This interference may affect interpretation of results of diagnostic tests in samples from patients with Parkinson’s disease treated with carbidopa and L-dopa. General significance: This mechanism allows prediction of interference in peroxidase-based diagnostic tests for other compounds, including drugs and natural products. |
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| 書誌情報 |
Biochimica et Biophysica Acta en : Biochimica et Biophysica Acta 巻 1862, 号 7, p. 1626-1634, 発行日 2018 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0304-4165 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bbagen.2018.04.007 | |||||
| 情報源 | ||||||
| 関連名称 | SC30201810090008 | |||||
| 情報源 | ||||||
| 関連名称 | NARO成果DBa | |||||
| 情報源 | ||||||
| 関連名称 | Green open access | |||||
| 情報源 | ||||||
| 関連名称 | This journal has an embargo period of 12 months. | |||||
| 情報源 | ||||||
| 関連名称 | この論文は出版社版ではありません。引用の際には出版社版をご利用ください。 | |||||
| 情報源 | ||||||
| 関連名称 | This is not the published version. Please cite only the published version. | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1016/j.bbagen.2018.04.007 | |||||
| 関連名称 | Biochimica et Biophysica Acta | |||||
