{"created":"2023-05-15T13:38:48.252005+00:00","id":2832,"links":{},"metadata":{"_buckets":{"deposit":"6d06fa48-6ef7-47f1-a597-0ce47495ed5a"},"_deposit":{"created_by":3,"id":"2832","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2832"},"status":"published"},"_oai":{"id":"oai:repository.naro.go.jp:00002832","sets":["2:581:63","87:551:680:50"]},"author_link":["2476","2163"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1634","bibliographicPageStart":"1626","bibliographicVolumeNumber":"1862","bibliographic_titles":[{"bibliographic_title":"Biochimica et Biophysica Acta"},{"bibliographic_title":"Biochimica et Biophysica Acta","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: A number of compounds, including ascorbic acid, catecholamines, flavonoids, p-diphenols and hydrazine derivatives have been reported to interfere with peroxidase-based medical diagnostic tests (Trinder reaction) but the mechanisms of these effects have not been fully elucidated.\nMethods: Reactions of bovine myeloperoxidase with o-dianisidine, bovine lactoperoxidase with ABTS and horse radish peroxidase with 4-aminoantipyrine/phenol in the presence of carbidopa, an anti-Parkinsonian drug, and other catechols, including L-dopa, were monitored spectrophotometrically and by measuring hydrogen peroxide consumption.\nResults: Chromophore formation in all three enzyme/substrate systems was blocked in the presence of carbidopa and other catechols. However, the rates of hydrogen peroxide consumption were not much affected. Irreversible enzyme inhibition was also insignificant. \nConclusions: Tested compounds reduced the oxidation products or intermediates of model substrates thus preventing chromophore formation. This interference may affect interpretation of results of diagnostic tests in samples from patients with Parkinson’s disease treated with carbidopa and L-dopa.\nGeneral significance: This mechanism allows prediction of interference in peroxidase-based diagnostic tests for other compounds, including drugs and natural products. \n","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbagen.2018.04.007","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"SC30201810090008"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"NARO成果DBa"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"Green open access"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"This journal has an embargo period of 12 months."}]},{"subitem_relation_name":[{"subitem_relation_name_text":"この論文は出版社版ではありません。引用の際には出版社版をご利用ください。"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"This is not the published version. Please cite only the published version."}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Biochimica et Biophysica Acta"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.bbagen.2018.04.007","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0304-4165","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yuki, Nishigaya"},{"creatorName":"ヤマザキ, トシマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"山崎, 俊正"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-16"}],"displaytype":"detail","filename":"SC30201810090008_postprintA.pdf","filesize":[{"value":"637.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"SC30201810090008_postprintA","url":"https://repository.naro.go.jp/record/2832/files/SC30201810090008_postprintA.pdf"},"version_id":"acb34fec-b725-4d6d-a88c-60f06f1d187e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"carbidopa","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"catechol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydrazine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peroxidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"enzymatic assay interference","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parkinson’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Interference of carbidopa and other catechols with reactions catalyzed by peroxidases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Interference of carbidopa and other catechols with reactions catalyzed by peroxidases"},{"subitem_title":"Interference of carbidopa and other catechols with reactions catalyzed by peroxidases","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["50","63"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-04"},"publish_date":"2019-10-04","publish_status":"0","recid":"2832","relation_version_is_last":true,"title":["Interference of carbidopa and other catechols with reactions catalyzed by peroxidases"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-02-22T01:48:13.172903+00:00"}