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Genome variability of foot-and-mouth disease virus during the short period of the 2010 epidemic in Japan
https://repository.naro.go.jp/records/162
https://repository.naro.go.jp/records/1624e6e195e-5449-4787-aba0-8ad8c8323d61
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
SC30201707200016_1-s2.0-S0378113516308306-main.pdf (638.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2017-02-01 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Genome variability of foot-and-mouth disease virus during the short period of the 2010 epidemic in Japan | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Genome variability of foot-and-mouth disease virus during the short period of the 2010 epidemic in Japan | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Foot-and-mouth disease virus | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Genome variability | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Comparative analysis | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Foot-and-mouth disease virus | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Genome variability | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Comparative analysis | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
西, 達也
× 西, 達也× 山田, 学× 深井, 克彦
WEKO
678
× 嶋田, 伸明
WEKO
1774
× 森岡, 一樹× 吉田, 和生× 坂本, 研一× 菅野, 徹× 山川, 睦 |
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Foot-and-mouth disease virus (FMDV) is highly contagious and has a high mutation rate, leading to extensive genetic variation. To investigate how FMDV genetically evolves over a short period of an epidemic after initial introduction into an FMD-free area, whole L-fragment sequences of 104 FMDVs isolated from the 2010 epidemic in Japan, which continued for less than three months were determined and phylogenetically and comparatively analyzed. Phylogenetic analysis of whole L-fragment sequences showed that these isolates were classified into a single group, indicating that FMDV was introduced into Japan in the epidemic via a single introduction. Nucleotide sequences of 104 virus isolates showed more than 99.56% pairwise identity rates without any genetic deletion or insertion, although no sequences were completely identical with each other. These results indicate that genetic substitutions of FMDV occurred gradually and constantly during the epidemic and generation of an extensive mutant virus could have been prevented by rapid eradication strategy. From comparative analysis of variability of each FMDV protein coding region, VP4 and 2C regions showed the highest average identity rates and invariant rates, and were confirmed as highly conserved. In contrast, the protein coding regions VP2 and VP1 were confirmed to be highly variable regions with the lowest average identity rates and invariant rates, respectively. Our data demonstrate the importance of rapid eradication strategy in an FMD epidemic and provide valuable information on the genome variability of FMDV during the short period of an epidemic. | |||||||||||||||||
| 書誌情報 |
Veterinary Microbiology en : Veterinary Microbiology 巻 199, p. 62-67, 発行日 2017-02 |
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| 出版者 | ||||||||||||||||||
| 出版者 | Elsevier B.V. | |||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0378-1135 | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | 10.1016/j.vetmic.2016.12.025 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | Copyright © 2017 Elsevier B.V. | |||||||||||||||||
| 情報源 | ||||||||||||||||||
| 関連名称 | SC30201707200016 | |||||||||||||||||
| 情報源 | ||||||||||||||||||
| 関連名称 | Gold Open Access | |||||||||||||||||
| 関連サイト | ||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.vetmic.2016.12.025 | |||||||||||||||||
| 関連名称 | Veterinary Microbiology | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
