@article{oai:repository.naro.go.jp:00000162,
 author = {西, 達也 and NISHI, Tatsuya and 山田, 学 and YAMADA, Manabu and 深井, 克彦 and FUKAI, Katsuhiko and 嶋田, 伸明 and SHIMADA, Nobuaki and 森岡, 一樹 and MORIOKA, Kazuki and 吉田, 和生 and YOSHIDA, Kazuo and 坂本, 研一 and SAKAMOTO, Kenichi and 菅野, 徹 and KANNO, Toru and 山川, 睦 and YAMAKAWA, Makoto},
 journal = {Veterinary Microbiology, Veterinary Microbiology},
 month = {Feb},
 note = {Foot-and-mouth disease virus (FMDV) is highly contagious and has a high mutation rate, leading to extensive genetic variation. To investigate how FMDV genetically evolves over a short period of an epidemic after initial introduction into an FMD-free area, whole L-fragment sequences of 104 FMDVs isolated from the 2010 epidemic in Japan, which continued for less than three months were determined and phylogenetically and comparatively analyzed. Phylogenetic analysis of whole L-fragment sequences showed that these isolates were classified into a single group, indicating that FMDV was introduced into Japan in the epidemic via a single introduction. Nucleotide sequences of 104 virus isolates showed more than 99.56% pairwise identity rates without any genetic deletion or insertion, although no sequences were completely identical with each other. These results indicate that genetic substitutions of FMDV occurred gradually and constantly during the epidemic and generation of an extensive mutant virus could have been prevented by rapid eradication strategy. From comparative analysis of variability of each FMDV protein coding region, VP4 and 2C regions showed the highest average identity rates and invariant rates, and were confirmed as highly conserved. In contrast, the protein coding regions VP2 and VP1 were confirmed to be highly variable regions with the lowest average identity rates and invariant rates, respectively. Our data demonstrate the importance of rapid eradication strategy in an FMD epidemic and provide valuable information on the genome variability of FMDV during the short period of an epidemic.},
 pages = {62--67},
 title = {Genome variability of foot-and-mouth disease virus during the short period of the 2010 epidemic in Japan},
 volume = {199},
 year = {2017},
 yomi = {ニシ, タツヤ and ヤマダ, マナブ and フカイ, カツヒコ and シマダ, ノブアキ and モリオカ, カズキ and ヨシダ, カズオ and サカモト, ケンイチ and カンノ, トオル and ヤマカワ, マコト}
}