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Restricted viral cDNA synthesis in cell lines that fail to support productive infection by bovine leukemia virus
https://repository.naro.go.jp/records/3395
https://repository.naro.go.jp/records/339541a94425-ca55-40ec-a201-9af5c749a0ac
| 名前 / ファイル | ライセンス | アクション |
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SC30201903060023_PostPrint (574.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-06-02 | |||||
| タイトル | ||||||
| タイトル | Restricted viral cDNA synthesis in cell lines that fail to support productive infection by bovine leukemia virus | |||||
| タイトル | ||||||
| タイトル | Restricted viral cDNA synthesis in cell lines that fail to support productive infection by bovine leukemia virus | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
鈴木, 孝子
× 鈴木, 孝子× 池田, 秀利× 真瀬, 昌司 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis, which results in significant economic losses on many affected farms. BLV infects a wide range of animals as well as cell lines derived from various mammalian species and organs; however, studies show that only some cell lines support sustained production of viral progeny. The differences between cells that produce viral progeny and those that do not are unclear. The aim of this study was to identify the steps of BLV replication that are associated with the capacity of a cell to support a productive infection. Eleven cell lines derived from various species were categorized into two groups, those that produce BLV progeny and those that do not, and the efficiency of viral attachment was compared. In addition, viral entry and reverse transcription were compared for two BLV-producing cell lines and three non-producing cell lines. BLV attached to and entered all of the tested cells. However, synthesis of viral DNA was inhibited in all three non-virus-producing cell lines, suggesting that BLV production was blocked either prior to or at the stage of reverse transcription. These results increase our understanding of the BLV life cycle and should enable better control over the 13 spread of BLV. | |||||
| 書誌情報 |
Archives of Virology en : Archives of Virology 巻 163, 号 9, p. 2415-2422, 発行日 2018-05-23 |
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| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1432-8798 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00705-018-3887-6 | |||||
| 権利 | ||||||
| 権利情報 | The Author(s) | |||||
| 情報源 | ||||||
| 関連名称 | SC30201903060023 | |||||
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| 関連名称 | NARO成果DBa | |||||
| 情報源 | ||||||
| 関連名称 | author manuscript | |||||
| 情報源 | ||||||
| 関連名称 | このアーカイブは著者版です。出版社版ではありません。引用の際には出版社版をご利用ください。 | |||||
| 情報源 | ||||||
| 関連名称 | This is not the published version. Please cite only the published version. | |||||
| 情報源 | ||||||
| 関連名称 | This is a post-peer-review, pre-copyedit version of an article published in [Archives of Virology]. | |||||
| 情報源 | ||||||
| 関連名称 | The final authenticated version is available online at: https://doi.org/10.1007/s00705-018-3887-6 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s00705-018-3887-6 | |||||
| 関連名称 | Archives of Virology | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
