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The effect of quercetin on genetic expression of the commensal gut microbes Bifidobacterium catenulatum, Enterococcus caccae and Ruminococcus gauvreauii
https://repository.naro.go.jp/records/321
https://repository.naro.go.jp/records/321a13bffd8-e84f-44c2-b3e1-696626910f70
| 名前 / ファイル | ライセンス | アクション |
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SC30201707070008_CCBY.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-04-17 | |||||
| タイトル | ||||||
| タイトル | The effect of quercetin on genetic expression of the commensal gut microbes Bifidobacterium catenulatum, Enterococcus caccae and Ruminococcus gauvreauii | |||||
| タイトル | ||||||
| タイトル | The effect of quercetin on genetic expression of the commensal gut microbes Bifidobacterium catenulatum, Enterococcus caccae and Ruminococcus gauvreauii | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Single molecule RNA sequencing | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Helicos technology | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Gut microbiota | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Quercetin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Polyphenol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Gene expression | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Single molecule RNA sequencing | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Helicos technology | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Gut microbiota | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Quercetin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Polyphenol | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Gene expression | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Firrman, Jenni
× Firrman, Jenni× Liu, LinShu× Zhang, Liqing× Argoty, Gustavo Arango× Tomasula, Peggy× KOBORI, Masuko× Pontious, Sherri× Xiao, Weidong× Wang, Minqian |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Quercetin is one of the most abundant polyphenols found in fruits and vegetables. The ability of the gut microbiota to metabolize quercetin has been previously documented; however, the effect that quercetin may have on commensal gut microbes remains unclear. In the present study, the effects of quercetin on the commensal gut microbes Ruminococcus gauvreauii, Bifidobacterium catenulatum and Enterococcus caccae were determined through evaluation of growth patterns and cell morphology, and analysis of genetic expression profiles between quercetin treated and non-treated groups using Single Molecule RNA sequencing via Helicos technology. Results of this study revealed that phenotypically, quercetin did not prevent growth of Ruminococcus gauvreauii, mildly suppressed growth of Bifidobacterium catenulatum, and moderately inhibited growth of Enterococcus caccae. Genetic analysis revealed that in response to quercetin, Ruminococcus gauvreauii down regulated genes responsible for protein folding, purine synthesis and metabolism. Bifidobacterium catenulatum increased expression of the ABC transport pathway and decreased metabolic pathways and cell wall synthesis. Enterococcus caccae upregulated genes responsible for energy production and metabolism, and downregulated pathways of stress response, translation and sugar transport. For the first time, the effect of quercetin on the growth and genetic expression of three different commensal gut bacteria was documented. The data provides insight into the interactions between genetic regulation and growth. This is also a unique demonstration of how RNA single molecule sequencing can be used to study the gut microbiota. | |||||
| 書誌情報 |
Anaerobe en : Anaerobe 巻 42, p. 130-141, 発行日 2016-12 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1075-9964 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.anaerobe.2016.10.004 | |||||
| 権利 | ||||||
| 権利情報 | This is an open access article under the CC BY license | |||||
| 情報源 | ||||||
| 関連名称 | SC30201707070008 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://dx.doi.org/10.1016/j.anaerobe.2016.10.004 | |||||
| 関連名称 | Anaerobe | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
