{"_buckets": {"deposit": "08226a64-caf0-47cf-8572-46bde9fb1e5b"}, "_deposit": {"created_by": 12, "id": "2811", "owners": [12], "pid": {"revision_id": 0, "type": "depid", "value": "2811"}, "status": "published"}, "_oai": {"id": "oai:repository.naro.go.jp:00002811", "sets": ["394"]}, "author_link": ["6694", "2336"], "item_10002_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-03-01", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "13", "bibliographicPageStart": "7", "bibliographicVolumeNumber": "71", "bibliographic_titles": [{"bibliographic_title": "食品総合研究所研究報告"}, {"bibliographic_title": "Report of National Food Research Institute", "bibliographic_titleLang": "en"}]}]}, "item_10002_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The effect of soy isoflavone on mRNA expression of sterol regulatory element-binding protein (SREBP)-1 isoforms and the target genes of SREBP-1 involved in fatty acid metabolism was examined in rats. Animals were fed a 20% palm oil diet containing 0, 0.05, 0.1, 0.2, or 0.4% of soy isoflavone for 14 d. The diets containing 0.1, 0.2, and 0.4% of isoflavone significantly increased the mRNA level of hepatic SREBP-1a to a similar level compared to a diet containing 0.05% of isoflavone or a diet free of isoflavone. In contrast, diets containing 0.05-0.2% isoflavone, compared to a diet free of isoflavone, did not influence the mRNA level of SREBP-1c. However, a diet containing 0.4% of isoflavone lowered this parameter to one half that observed with an isoflavone-free diet. Dietary isoflavone dose-dependently increased the mRNA levels of genes targeted by SREBP-1 (fatty acid synthase, stearoyl-CoA desaturase 1 and Δ^6-desaturase), and they peaked at a dietary level of 0.1 or 0.2%. However, a diet containing 0.4% of isoflavone decreased these parameters to the levels observed in rats fed an isoflavone-free diet. Thus, it is apparent that varying amounts of dietary isoflavone modulate mRNA expressions of SREBP-1a and -1c differently. The contours of the changes in the gene expressions of SREBP-1 isoforms may account for the biphasic modulation by different dietary levels of isoflavone in the mRNA expression of the genes targeted by these transcriptional factors.", "subitem_description_type": "Abstract"}, {"subitem_description": "大豆イソフラボンが脂肪酸代謝に関わる転写因子、ステロール調節エレメント結合タンパク質 (SREBP) -1と、SREBP-1に応答する脂肪酸代謝系遺伝子の発現に及ぼす影響をラットで調べた。ラットに0、0.05、0.1、0.2、または0.4%の大豆イソフラボンを含む20%パーム油食を与え、14日間飼育した。肝臓のSREBP-1aのmRNA発現量は、イソフラボン無添加食群、または0.05%イソフラボン食群と比べ、0.1%以上のイソフラボンを含む食餌群で増加した。SREBP-1cの発現は、イソフラボン無添加食群と比べ0.05-0.2%イソフラボン食群では差はなかったが、0.4%イソフラボン食群では約50%減少した。SREBP-1に応答する脂肪酸合成酵素や脂肪酸不飽和化酵素の遺伝子発現は、食餌へのイソフラボン添加で増加し、0.1または0.2%イソフラボン食群で最大値を示したが、0.4%イソフラボン食群ではイソフラボン無添加食と同程度の発現量にまで減少した。以上のように、SREBP-1aとSREBP-1cのmRNA発現量は食餌中のイソフラボン添加量に従って互いに異なった変化を示した。食餌へのイソフラボン添加量に呼応したSREBP-1依存性遺伝子発現量の二相性の変化は、このようなSREBP-1アイソフォームのmRNA発現変化に起因すると考えられた。", "subitem_description_type": "Abstract"}]}, "item_10002_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24514/00002693", "subitem_identifier_reg_type": "JaLC"}]}, "item_10002_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "農業・食品産業技術総合研究機構"}]}, "item_10002_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.24514/00002693", "subitem_relation_type_select": "DOI"}}]}, "item_10002_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0301-9780", "subitem_source_identifier_type": "ISSN"}]}, "item_10002_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "高橋, 陽子"}, {"creatorName": "タカハシ, ヨウコ", "creatorNameLang": "ja-Kana"}, {"creatorName": "TAKAHASHI, Yoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2336", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50353933", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50353933"}, {"nameIdentifier": "read0005776", "nameIdentifierScheme": "researchmap", "nameIdentifierURI": "http://researchmap.jp/read0005776"}]}, {"creatorNames": [{"creatorName": "井手, 隆"}, {"creatorName": "イデ, タカシ", "creatorNameLang": "ja-Kana"}, {"creatorName": "IDE, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6694", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000000283695", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000000283695"}, {"nameIdentifier": "read0004155", "nameIdentifierScheme": "researchmap", "nameIdentifierURI": "http://researchmap.jp/read0004155"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-10-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "nfri_report_No71p7-14p.pdf", "filesize": [{"value": "263.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 263500.0, "url": {"label": "nfri_report_No71p7-14p.pdf", "url": "https://repository.naro.go.jp/record/2811/files/nfri_report_No71p7-14p.pdf"}, "version_id": "1207d923-7c06-4f79-b155-4f21109d91d9"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "大豆イソフラボンが高飽和脂肪食摂取ラット肝臓のSREBP-1応答遺伝子の発現に与える影響", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "大豆イソフラボンが高飽和脂肪食摂取ラット肝臓のSREBP-1応答遺伝子の発現に与える影響"}, {"subitem_title": "Alteration by dietary soy isoflavone of SERBP-1-dependent genes in the liver of rats fed a high saturated-fat diet", "subitem_title_language": "en"}]}, "item_type_id": "10002", "owner": "12", "path": ["394"], "permalink_uri": "https://doi.org/10.24514/00002693", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-12-20"}, "publish_date": "2019-12-20", "publish_status": "0", "recid": "2811", "relation": {}, "relation_version_is_last": true, "title": ["大豆イソフラボンが高飽和脂肪食摂取ラット肝臓のSREBP-1応答遺伝子の発現に与える影響"], "weko_shared_id": 12}