{"created":"2023-05-15T13:39:11.615232+00:00","id":3339,"links":{},"metadata":{"_buckets":{"deposit":"6289d48e-0ae6-4b37-ae7d-86fa7090aac9"},"_deposit":{"created_by":11,"id":"3339","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3339"},"status":"published"},"_oai":{"id":"oai:repository.naro.go.jp:00003339","sets":["2:581:105","87:654:46"]},"author_link":["6947","1408","1838","6495","2143","868"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"130","bibliographicPageStart":"125","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"Immunogenetics"},{"bibliographic_title":"Immunogenetics","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The NLRC4 inflammasome, which recognizes flagellin and components of the type III secretion system, plays an important role in the clearance of intracellular bacteria. Here, we examined the genomic sequences carrying two genes encoding key components of the NLRC4 inflammasome—NLR family, CARD-containing 4 (NLRC4), and NLR apoptosis inhibitory protein (NAIP)—in pigs. Pigs have a single locus encoding NLRC4 and NAIP. Comparison of the sequences thus obtained with the corresponding regions in humans revealed the deletion of intermediate exons in both pig genes. In addition, the genomic sequences of both pig genes lacked valid open reading frames encoding functional NLRC4 or NAIP protein. Additional pigs representing multiple breeds and wild boars also lacked the exons that we failed to find through genome sequencing. Furthermore, neither the NLRC4 nor the NAIP gene was expressed in pigs. These findings indicate that pigs lack the NLRC4 inflammasome, an important factor involved in monitoring bacterial proteins and contributing to the clearance of intracellular pathogens. These results also suggest that genetic polymorphisms affecting the molecular functions of TLR2, TLR4, TLR5, and other pattern recognition receptors associated with the recognition of bacteria have a more profound influence on disease resistance in pigs than in other species.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Published by Springer Berlin Heidelberg"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00251-016-0955-5","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"SC30201802140027"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"NARO成果DBa "}]},{"subitem_relation_name":[{"subitem_relation_name_text":"This is a post-peer-review, pre-copyedit version of an article published in [Immunogenetics]. "}]},{"subitem_relation_name":[{"subitem_relation_name_text":"The final authenticated version is available online at: http://dx.doi.org/10.1007/s00251-016-0955-5"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"This is not the published version. Please cite only the published version. "}]},{"subitem_relation_name":[{"subitem_relation_name_text":"この論文は出版社版ではありません。引用の際には出版社版をご利用ください。"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Immunogenetics"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dx.doi.org/10.1007/s00251-016-0955-5","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1432-1211","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐久間, 智理"},{"creatorName":"サクマ, チサト","creatorNameLang":"ja-Kana"},{"creatorName":"SAKUMA, Chisato","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"新開, 浩樹"},{"creatorName":"シンカイ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"SHINKAI, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"竹之内, 敬人"},{"creatorName":"タケノウチ, タカト","creatorNameLang":"ja-Kana"},{"creatorName":"TAKENOUCHI, Takato","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"佐藤, 充"},{"creatorName":"サトウ, ミツル","creatorNameLang":"ja-Kana"},{"creatorName":"SATO, Mitsuru","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"木谷, 裕"},{"creatorName":"キタニ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"KITANI, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"上西, 博英"},{"creatorName":"ウエニシ, ヒロヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"UENISHI, Hirohide","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-01"}],"displaytype":"detail","filename":"SC30201802140027_PostPrint-a.pdf","filesize":[{"value":"502.0 kB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"C30201802140027_PostPrint","url":"https://repository.naro.go.jp/record/3339/files/SC30201802140027_PostPrint-a.pdf"},"version_id":"3d96857a-3c8d-4cd2-9b52-695cb05b8cad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Genome sequencing","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammasome","subitem_subject_scheme":"Other"},{"subitem_subject":"Pattern recognition receptors","subitem_subject_scheme":"Other"},{"subitem_subject":"Swine","subitem_subject_scheme":"Other"},{"subitem_subject":"Genome sequencing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammasome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pattern recognition receptors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Swine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pig lacks functional NLRC4 and NAIP genes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pig lacks functional NLRC4 and NAIP genes"},{"subitem_title":"Pig lacks functional NLRC4 and NAIP genes","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"11","path":["46","105"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-06"},"publish_date":"2020-01-06","publish_status":"0","recid":"3339","relation_version_is_last":true,"title":["Pig lacks functional NLRC4 and NAIP genes"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T15:29:57.476827+00:00"}