{"created":"2023-05-15T13:38:56.433307+00:00","id":2990,"links":{},"metadata":{"_buckets":{"deposit":"a846840b-6f23-4b2d-ac18-9e2da422e8e6"},"_deposit":{"created_by":12,"id":"2990","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"2990"},"status":"published"},"_oai":{"id":"oai:repository.naro.go.jp:00002990","sets":["87:627:628:388:398"]},"author_link":["330","6627","325"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"23","bibliographicPageStart":"17","bibliographicVolumeNumber":"75","bibliographic_titles":[{"bibliographic_title":"食品総合研究所研究報告"},{"bibliographic_title":"Report of National Food Research Institute","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Caffeine, a natural component of coffee and tea, is one of the most widely consumed drugs in the world. Caffeine can interact with several cell-surface receptors (e.g., adenosine receptors) and can modulate various cellular functions by binding to these receptors. However, there are few reports on its immunological functions. Therefore, we investigated the effects of caffeine on in vitro antigen-specific immune responses of unsensitized (naïve) immune cells from transgenic mice expressing the ovalbumin-specific T-cell receptor (TCR). Caffeine treatment significantly suppressed the proliferation of splenocytes and the secretion of interleukin (IL)-2, IL-4, and IL-10 elicited by ovalbumin stimulation. Moreover, immunoglobulin (Ig) G1 secretion was downregulated. In contrast, antigen-specific secretion of IL-12p40, IL-5, IgG2a, and IgA were not affected. These results suggest that caffeine treatment alters antigen-specific immune responses of primary naïve immune cells.","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24514/00002870","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"農業・食品産業技術総合研究機構"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.24514/00002870","subitem_relation_type_select":"DOI"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0301-9780","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"後藤, 真生"},{"creatorName":"ゴトウ, マサオ","creatorNameLang":"ja-Kana"},{"creatorName":"GOTO, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"ISHIKAWA-TAKANO, Yuko","creatorNameLang":"en"},{"creatorName":"石川（高野）, 祐子","creatorNameLang":"ja"},{"creatorName":"イシカワ（タカノ）, ユウコ","creatorNameLang":"ja-Kana"},{"creatorName":"TAKANO-ISHIKAWA, Yuko","creatorNameLang":"en"}],"familyNames":[{},{},{},{}],"givenNames":[{},{},{},{}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"新本, 洋士"},{"creatorName":"シンモト, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"SHINMOTO, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-07"}],"displaytype":"detail","filename":"nfri_report_No75p17-23p.pdf","filesize":[{"value":"311.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"nfri_report_No75p17-23p.pdf","url":"https://repository.naro.go.jp/record/2990/files/nfri_report_No75p17-23p.pdf"},"version_id":"26f2a55d-4873-48e6-aa51-ba23a84cc9d8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"caffeine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"naïve immune cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immune responses","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of caffeine on antigen-specific immune responses of mouse splenocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of caffeine on antigen-specific immune responses of mouse splenocytes"},{"subitem_title":"Effect of caffeine on antigen-specific immune responses of mouse splenocytes","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"12","path":["398"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-20"},"publish_date":"2019-12-20","publish_status":"0","recid":"2990","relation_version_is_last":true,"title":["Effect of caffeine on antigen-specific immune responses of mouse splenocytes"],"weko_creator_id":"12","weko_shared_id":12},"updated":"2023-07-20T06:23:59.382542+00:00"}