{"created":"2023-05-15T13:38:18.795710+00:00","id":2224,"links":{},"metadata":{"_buckets":{"deposit":"0c3a6456-7d88-42c9-92a1-a2163910eaa7"},"_deposit":{"created_by":12,"id":"2224","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"2224"},"status":"published"},"_oai":{"id":"oai:repository.naro.go.jp:00002224","sets":["87:623:622:129:266"]},"author_link":["137","212","1171","5835","5859"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-09-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"44","bibliographicPageStart":"39","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"九州沖縄農業研究センター報告"},{"bibliographic_title":"Bulletin of the NARO Kyushu Okinawa Agricultural Research Center","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Functional elements caffeic acid and caffeoylquinic acid (CQA) derivatives are contained in the stems and leaves of sweetpotato variety \"Suioh\" CQA derivatives are expected to inhibit angiotensin I-converting enzyme (ACE) and thus to lower the blood pressure level. The interactions between six CQA derivatives and ACE were analyzed by using surface plasmon resonance (SPR) biosensors. Affinity analysis was performed, and then KD values were calculated with the installed software. The KD values were found to be 3, 4, 5-O-triCQA, 4, 5-O-diCQA, 3, 4-O-diCQA, chlorogenic acid, 3, 5-O-diCQA, and caffeic acid in ascending order. The previously obtained correlation coefficient between KD and IC_50 was r=0.901^**. The high and positive correlation obtained suggested that this may be a promising new analysis method\n","subitem_description_type":"Abstract"},{"subitem_description":"表面プラズモン共鳴バイオセンサーを用い, サツマイモの茎葉に含有される機能性成分であるカフェオイルキナ酸類と血圧上昇に関与するアンギオテンシン I 変換酵素との相互作用を測定し, 解離定数を算出した。その結果, 解離定数は3, 4, 5-O-triCQA が最も小さく, 次いで, 4, 5-O-diCQA, クロロゲン酸, 3, 4-O-diCQA, 3, 5-O-diCQA, カフェ酸の順であった。さらに, 解離定数と従来法で得られたアンギオテンシン I 変換酵素50%阻害濃度との相関を求めたところ, r=0.901^**となり高い正の相関関係が認められた。このことから, 表面プラズモン共鳴バイオセンサーはアンギオテンシン I 変換酵素阻害活性の新たな評価法として利用が期待できることが示された。\n","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24514/00002133","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"独立行政法人 農業・食品産業技術総合研究機構 九州沖縄農業研究センター"}]},"item_10002_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.24514/00002133","subitem_relation_type_select":"DOI"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-9177","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"波多野, 哲也"},{"creatorName":"ハタノ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"HATANO, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1171","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90414812","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90414812"},{"nameIdentifier":"tetsuyahatano","nameIdentifierScheme":"researchmap","nameIdentifierURI":"http://researchmap.jp/tetsuyahatano"}]},{"creatorNames":[{"creatorName":"氏原, 邦博"},{"creatorName":"ウジハラ, クニヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"UJIHARA, Kunihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"137","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000003039390","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000003039390"},{"nameIdentifier":"70414844","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70414844"}]},{"creatorNames":[{"creatorName":"石黒, 浩二"},{"creatorName":"イシグロ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"ISHIGURO, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"212","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40414825","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40414825"},{"nameIdentifier":"i-koji","nameIdentifierScheme":"researchmap","nameIdentifierURI":"http://researchmap.jp/i-koji"}]},{"creatorNames":[{"creatorName":"吉元, 誠"},{"creatorName":"ヨシモト, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"YOSHIMOTO, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 哲生"},{"creatorName":"サトウ, テツオ","creatorNameLang":"ja-Kana"},{"creatorName":"SATO, Tetsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5859","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-20"}],"displaytype":"detail","filename":"konarc_report_No56p39-44p.pdf","filesize":[{"value":"587.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"konarc_report_No56p39-44p.pdf","url":"https://repository.naro.go.jp/record/2224/files/konarc_report_No56p39-44p.pdf"},"version_id":"efbc5146-bfd8-47ff-955c-1ebaf6c95277"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"サツマイモ茎葉","subitem_subject_scheme":"Other"},{"subitem_subject":"すいおう","subitem_subject_scheme":"Other"},{"subitem_subject":"アンギオテンシン I 変換酵素阻害活性","subitem_subject_scheme":"Other"},{"subitem_subject":"カフェオイルキナ酸類","subitem_subject_scheme":"Other"},{"subitem_subject":"表面プラズモン共鳴バイオセンサー","subitem_subject_scheme":"Other"},{"subitem_subject":"Sweetpotato tops","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Suioh","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiotensin I-converting enzyme (ACE) inhibitory activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"caffeoylquinic acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"surface plasmon resonance (SPR) biosensor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"表面プラズモン共鳴バイオセンサーによるサツマイモ品種すいおうに含まれるカフェオイルキナ酸類とアンギオテンシン I 変換酵素との相互作用解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"表面プラズモン共鳴バイオセンサーによるサツマイモ品種すいおうに含まれるカフェオイルキナ酸類とアンギオテンシン I 変換酵素との相互作用解析"},{"subitem_title":"Using Surface Plasmon Resonance (SPR) Biosensors for Analyzing the Interaction Between Caffeoylquinic Acid Derivatives Contained in the Stems and Leaves of Sweetpotato Variety \"Suioh\" and Angiotensin I-converting Enzyme","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"12","path":["266"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-22"},"publish_date":"2019-03-22","publish_status":"0","recid":"2224","relation_version_is_last":true,"title":["表面プラズモン共鳴バイオセンサーによるサツマイモ品種すいおうに含まれるカフェオイルキナ酸類とアンギオテンシン I 変換酵素との相互作用解析"],"weko_creator_id":"12","weko_shared_id":12},"updated":"2023-05-15T15:55:03.724092+00:00"}