@article{oai:repository.naro.go.jp:00001895,
 author = {川嶌, 健司 and KAWASHIMA, Kenji and 恒光, 裕 and TSUNEMITSU, Hiroshi and 堀野, 理恵子 and HORINO, Rieko and 勝田, 賢 and KATSUDA, Ken and 庄司, 智太郎 and SHOJI, Tomotaro and 小野寺, 利幸 and ONODERA, Toshiyuki and 播谷, 亮 and HARITANI, Makoto and 村上, 洋介 and MURAKAMI, Yosuke and 久保, 正法 and KUBO, Masanori and 池田, 秀利 and IKEDA, Hidetoshi and 加来, 義浩 and KAKU, Yoshihiro and 木村, 久美子 and KIMURA, Kumiko and 谷村, 信彦 and TANIMURA, Nobuhiko},
 journal = {動物衛生研究所研究報告, Bulletin of the National Institute of Animal Health},
 month = {Mar},
 note = {Postweaning multisystemic wasting syndrome (PMWS) is an emerging infectious disease associated with the infection of porcine circovirus type 2 (PCV2), which was newly recognized in Canada in 1998. Since there was no available information on the actual condition regarding PMWS in Japan, specific methods for diagnosis of this syndrome were developed, and the pathogenesis of PMWS was studied by a pathophysiological analysis of the affected pigs, an experimental infection of PCV2, and a survey for the prevalence of PMWS and PCV2. In the results, the peripheral lymphocyte count was reduced in pigs affected with PMWS, and pretreatment with dexamethasone exacerbated PCV2 multiplication and lesion formation in the lymphoid tissue of the pigs inoculated with PCV2, suggesting that the immune status of the host might be related to the pathogenesis of PMWS. The epidemiological studies demonstrated that PCV2 is widely distributed in pigs and, furthermore, there is a large population with subclinical infection., 離乳後多臓器性発育不良症候群（ p o s t w e a n i n g multisystemic wasting syndrome：PMWS）は, 1998年にカナダで新たに見つかったブタサーコウイルス2型（PCV2）が関与する豚の新興感染病である. わが国におけるPMWSの実態を明らかにするために, PCV2抗体の検出法, PCRによる遺伝子診断法および免疫組織学的検出法を開発し, PMWS発症豚の病態解析, 実験感染および全国規模のPMWSの実態調査を行った. その結果, PMWS発症豚の抹消血リンパ球は減少していること, ならびにデキサメタゾンの前投与によってPCV2感染豚のリンパ組織におけるPCV2の増殖と病変形成が増強されることを明らかにし,  PMWSの病理発生に宿主の免疫状態が関連する可能性を示唆した. 疫学調査結果から, PCV2がわが国に広く浸潤していること, また, PCV2は検出されるがPMWS病変を持たない豚が高率に存在することが明らかとなった.},
 pages = {9--16},
 title = {わが国の豚における離乳後多臓器性発育不良症候群 (PMWS) の実態解明},
 volume = {109},
 year = {2003},
 yomi = {カワシマ, ケンジ and ツネミツ, ヒロシ and ホリノ, リエコ and カツダ, ケン and ショウジ, トモタロウ and オノデラ, トシユキ and ハリタニ, マコト and ムラカミ, ヨウスケ and クボ, マサノリ and イケダ, ヒデトシ and カク, ヨシヒロ and キムラ, クミコ and タニムラ, ノブヒコ}
}