@article{oai:repository.naro.go.jp:00000121,
 author = {沖, 智之 and OKI, Tomoyuki and 狩野, 光芳 and KANO, Mitsuyoshi and 渡邉, 治 and WATANABE, Osamu and 後藤, 一寿 and GOTO, Kazuhisa and BOELSMA, Esther and BOELSMA, Esther and 石川, 文保 and ISHIKAWA, Fumiyasu and 須田, 郁夫 and SUDA, Ikuo},
 issue = {3},
 journal = {Bioscience of Microbiota, Food and Health, Bioscience of Microbiota, Food and Health},
 month = {Jul},
 note = {An open-label study with one treatment arm was conducted to investigate changes in health-related biomarkers (blood pressure and liver enzyme activity) and the safety of 4 weeks of consuming a purple-fleshed sweet potato beverage in Caucasian subjects. Twenty healthy adults, 18?70 years of age, with a body mass index >25 kg/m2, elevated blood pressure and elevated levels of liver function biomarkers consumed two cartons of purple-fleshed sweet potato beverage (125 ml, including 117 mg anthocyanin per carton) daily for 4 weeks. Hematology, serum clinical profile, dipstick urinalysis and blood pressure were determined before consumption, at 2 and 4 weeks of consumption and after a 2-week washout period. A trend was found toward lowering systolic blood pressure during the treatment period (p=0.0590). No significant changes were found in diastolic blood pressure throughout the study period. Systolic blood
pressure was significantly lower after 4 weeks of consumption compared with before consumption (p=0.0125) and was significantly higher after the 2-week washout period compared with after consumption (p=0.0496). The serum alanine aminotransferase level significantly increased over time, but aspartate aminotransferase and γ-glutamyltransferase levels stayed within the normal range of reference values. Safety parameters of the blood and urine showed no clinically relevant changes. The consumption of a purple-fleshed sweet potato beverage for 4 weeks resulted in no clinically relevant changes in safety parameters of the blood and urine and showed a trend toward lowering systolic blood pressure.},
 pages = {129--136},
 title = {Effect of consuming a purple-fleshed sweet potato beverage on health-related biomarkers and safety parameters in Caucasian subjects with elevated levels of blood pressure and liver function biomarkers: a 4-week, open-label, non-comparative trial},
 volume = {35},
 year = {2016},
 yomi = {オキ, トモユキ and カノ, ミツヨシ and ワタナベ, オサム and ゴトウ, カズヒサ and イシカワ, フミヤス and スダ, イクオ}
}